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Article

Simultaneous and multiplexed phenotyping of circulating exosomes with the orthogonal CRISPR-Cas platform.

Chemical communications (Cambridge, England) - 4 Jun 2024

Su Gaoxing, Xu Mengting, Zhu Yuedong, Zhang Yan, Lin Yanan, Yu Yanyan

Abstract excerpt

Simultaneous and multiplexed exosome protein profiling via an orthogonal CRISPR-Cas platform was achieved in this work. Aptamers were recruited to translate exosome surface protein information into Cas12a/Cas13a cleavage activity. The established multiplexed platform performed robustly with biological matrixes and could profile exosome proteins in clinical serum samples.

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PMID: 38764375
DOI: 10.1039/d4cc00497c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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