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Article

The clonal hematopoiesis mutation Jak2V617F aggravates endothelial injury and thrombosis in arteries with erosion-like intimas.

International journal of cardiology - 15 Aug 2024

Molinaro Roberto, Sellar Rob S, Vromman Amélie, Sausen Grasiele, Folco Eduardo, Sukhova Galina K, McConke Marie E, Corbo Claudia, Ebert Benjamin L, Libby Peter

Abstract excerpt

BACKGROUND: Superficial plaque erosion causes many acute coronary syndromes. However, mechanisms of plaque erosion remain poorly understood, and we lack directed therapeutics for thrombotic complication. Human eroded plaques can harbor neutrophil extracellular traps (NETs) that propagate endothelial damage at experimental arterial lesions that recapitulate superficial erosion. Clonal Hematopoiesis of...

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Source

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Identifiers

PMID: 38759798
DOI: 10.1016/j.ijcard.2024.132184
PMCID: PMC11753411

Genes

JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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