Article
Comparative effects of different antiplatelet strategies in carriers of CYP2C19 loss-of-function alleles: a network meta-analysis.
European heart journal. Cardiovascular pharmacotherapy - 4 Oct 2024
Galli Mattia, Occhipinti Giovanni, Benenati Stefano, Laborante Renzo, Ortega-Paz Luis, Franchi Francesco, D'Amario Domenico, Nerla Roberto, Castriota Fausto, Frati Giacomo, Biondi-Zoccai Giuseppe, Sciarretta Sebastiano, Angiolillo Dominick J
Abstract excerpt
BACKGROUND: Carriers of cytochrome 2C19 (CYP2C19) loss-of-function (LoF) alleles treated with clopidogrel have impaired drug metabolism, resulting in reduced active metabolite levels, high platelet reactivity (HPR), and an increased risk of thrombotic events. Several alternative antiplatelet therapies have been proposed to overcome HPR in these patients, but their comparative effects remain poorly explored....
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