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Article

Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy.

Circulation - 23 Jul 2024

Yang Ping, Lou Yingmei, Geng Zilong, Guo Zhizhao, Wu Shuo, Li Yige, Song Kaiyuan, Shi Ting, Zhang Shasha, Xiong Junhao, Chen Alex F, Li Dali, Pu William T, Da Lintai, Zhang Yan, Sun Kun, Zhang Bing

Abstract excerpt

BACKGROUND: Familial hypertrophic cardiomyopathy has severe clinical complications of heart failure, arrhythmia, and sudden cardiac death. Heterozygous single nucleotide variants (SNVs) of sarcomere genes such as MYH7 are the leading cause of this type of disease. CRISPR-Cas13 (clustered regularly interspaced short palindromic repeats and their associated protein 13) is an emerging gene therapy approach for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38752340
DOI: 10.1161/CIRCULATIONAHA.123.067890
PMCID: PMC11259241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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