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Identification and characterization of a nonbiological small-molecular mimic of a Zika virus conformational neutralizing epitope

14 May 2024

Abstract excerpt

Antigenic similarities between Zika virus (ZIKV) and other flaviviruses pose challenges to the development of virus-specific diagnostic tools and effective vaccines. Starting with a DNA-encoded one-bead-one-compound combinatorial library of 508,032 synthetic, non-natural oligomers, we selected and characterized small molecules that mimic ZIKV epitopes. High-throughput fluorescence-activated cell sorter-based bead...

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PMID: 38743628
DOI: 10.1073/pnas.2312755121

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