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Article

Biofilm-associated metabolism via ERG251 in Candida albicans.

PLoS pathogens - 1 May 2024

Xiong Liping, Pereira De Sa Nivea, Zarnowski Robert, Huang Manning Y, Mota Fernandes Caroline, Lanni Frederick, Andes David R, Del Poeta Maurizio, Mitchell Aaron P

Abstract excerpt

Biofilm formation by the fungal pathogen Candida albicans is the basis for its ability to infect medical devices. The metabolic gene ERG251 has been identified as a target of biofilm transcriptional regulator Efg1, and here we report that ERG251 is required for biofilm formation but not conventional free-living planktonic growth. An erg251Δ/Δ mutation impairs biofilm formation in vitro and in an in vivo catheter...

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Source

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Identifiers

PMID: 38739655
DOI: 10.1371/journal.ppat.1012225
PMCID: PMC11115363

Genes

GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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