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Article

Prime editing-mediated correction of the leptin receptor in muscle cells of db/db mice.

Biotechnology journal - 1 May 2024

Lee Kyung Eun, Xu Yanping, Geng Bingchuan, Kim Jongsoo, Kellon Natalie, He Zhixian, Zhang Zhentao, Li Deqiang, Gouchoe Doug A, Zhu Hua

Abstract excerpt

Genetic diseases can be caused by monogenic diseases, which result from a single gene mutation in the DNA sequence. Many innovative approaches have been developed to cure monogenic genetic diseases, namely by genome editing. A specific type of genomic editing, prime editing, has the potential advantage to edit the human genome without requiring double-strand breaks or donor DNA templates for editing....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38730523
DOI: 10.1002/biot.202300676
PMCID: PMC11090457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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