Assessment of CD8+ T-cell mediated immunity in an influenza A(H3N2) human challenge model in Belgium: a single centre, randomised, double-blind phase 2 study

Abstract excerpt

Background Protection afforded by inactivated influenza vaccines can theoretically be improved by inducing T-cell responses to conserved internal influenza A antigens. We assessed whether, in an influenza controlled human infection challenge, susceptible individuals receiving a vaccine boosting T-cell responses would exhibit lower viral load and decreased symptoms compared with placebo recipients. Methods In this...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Immune responses and vaccinations
• Share to Influenza Virus Research Studies
• Share to T-cell and B-cell Immunology