Article
Association of tuberculosis risk with genetic polymorphisms of the immune checkpoint genes PDCD1, CTLA-4, and TIM3.
PloS one - 1 Jan 2024
Liu Chi-Wei, Wu Lawrence Shih-Hsin, Lin Chou-Jui, Wu Hsing-Chu, Liu Kuei-Chi, Lee Shih-Wei
Abstract excerpt
The immune checkpoint proteins were reported to involve to host resistance to Mycobacteria tuberculosis (Mtb). Here, we evaluated 11 single nucleotide polymorphisms (SNPs) in PDCD1, CTLA4, and HAVCR2 genes between participants with and without TB infection. Genomic DNA isolated from 285 patients with TB and 270 controls without TB infection were used to perform the genotyping assay. Odds ratios were used to...
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