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Machine learning-based algorithm identifies key mitochondria-related genes in non-alcoholic steatohepatitis

8 May 2024

Abstract excerpt

BACKGROUND: Evidence suggests that hepatocyte mitochondrial dysfunction leads to abnormal lipid metabolism, redox imbalance, and programmed cell death, driving the onset and progression of non-alcoholic steatohepatitis (NASH). Identifying hub mitochondrial genes linked to NASH may unveil potential therapeutic targets. METHODS: Mitochondrial hub genes implicated in NASH were identified via analysis using 134...

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PMID: 38720280
DOI: 10.1186/s12944-024-02122-z

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