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Exploring the extrachromosomal plasmid rDNA of Naegleria fowleri AY27 genotype II: A human brain-eating amoeba via high-throughput sequencing.

BMC medical genomics - 7 May 2024

Aurongzeb Muhammad, Talha Malik Hafiz Muhammad, Jahanzaib Muhammad, Hassan Syed Shah, Rashid Yasmeen, Aziz Tariq, Alharbi Metab

Abstract excerpt

Naegleria fowleri, also known as brain-earing amoeba, causes severe and rapidly fatal CNS infection in humans called primary amebic meningoencephalitis (PAM). The DNA from the N. fowleri clinical isolate was sequenced for circular extrachromosomal ribosomal DNA (CERE - rDNA). The CERE contains 18 S, 5.8 S, and 28 S ribosomal subunits separated by internal transcribed spacers, 5 open reading frames (ORFs), and...

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PMID: 38715056
DOI: 10.1186/s12920-024-01890-y
PMCID: PMC11075319

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