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Article

Interleukin-6-Positive Immune Cells as a Possible New Immunologic Marker Associated With the Colorectal Cancer Prognosis.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2024

Gulubova Maya, Chonov Dimitur, Aleksandrova Elina, Ivanova Koni, Ignatova M Magdalena, Vlaykova Tatyana

Abstract excerpt

Chronic inflammation creates tumor microenvironment (TME) that facilitates colorectal cancer (CRC) cell proliferation, migration, metastasis, and tumor progression. Interleukin-6 (IL-6) is a proinflammatory cytokine with a pleiotropic effect on CRC development. We aimed to evaluate IL-6 expression in tumor cells and in immune cells in TME, to assess the serum level and IL6 -174 G/C genotype distribution and to...

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Source

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Identifiers

PMID: 38712586
DOI: 10.1097/PAI.0000000000001198
PMCID: PMC11073565

Genes

IL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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