Article
Association of Matrix Metalloproteinase-2 (MMP-2) and MMP-9 Promoter Variants, Their Serum Levels, and Activities with Aortic Valve Calcification (AVC) in a Population from Western Iran.
Genetic testing and molecular biomarkers - 1 Jun 2024
Heidari Moghadam Reza, Babajani Fatemeh, Karami Afshin, Elieh-Ali-Komi Daniel, Hoseini Faeghe, Salehi Nahid, Elahirad Saeed, Mohammadi-Noori Ehsan, Mohammadi Hossein, Kiani Amir
Abstract excerpt
Background: Matrix metalloproteinase (MMP) enzyme gene polymorphisms MMP-2-1575G/A and MMP-9-1562C/T promoter polymorphism, their serum levels, and activity are associated with aortic valve calcification (AVC). Materials and Methods: The synergistic link between the risk of AVC and the alleles T and A of MMP-9 and MMP-2 was investigated, respectively. Ninety-two cases with AVC and 92 healthy individuals from the...
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