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HDAC inhibitors activate lipid peroxidation and ferroptosis in gastric cancer

4 May 2024

Abstract excerpt

Gastric cancer remains among the deadliest neoplasms worldwide, with limited therapeutic options. Since efficacies of targeted therapies are unsatisfactory, drugs with broader mechanisms of action rather than a single oncogene inhibition are needed. Preclinical studies have identified histone deacetylases (HDAC) as potential therapeutic targets in gastric cancer. However, the mechanism(s) of action of HDAC...

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Share to Epigenetics and DNA Methylation
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Share to Histone Deacetylase Inhibitors Research

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PMID: 38705532
DOI: 10.1016/j.bcp.2024.116257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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