Article
Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression.
Metabolism: clinical and experimental - 1 Mar 2021
Nimer Nisreen, Choucair Ibrahim, Wang Zeneng, Nemet Ina, Li Lin, Gukasyan Janet, Weeks Taylor L, Alkhouri Naim, Zein Nizar, Tang W H Wilson, Fischbach Michael A, Brown J Mark, Allayee Hooman, Dasarathy Srinivasan, Gogonea Valentin, Hazen Stanley L
Abstract excerpt
OBJECTIVE: Metabolomic studies suggest plasma levels of bile acids (BAs) are elevated amongst subjects with non-alcoholic fatty liver disease (NAFLD) compared to healthy controls. However, it remains unclear whether or not specific BAs are associated with the clinically relevant transition from nonalcoholic fatty liver (i.e. simple steatosis) to non-alcoholic steatohepatitis (NASH), or enhanced progression of...
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