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Discovery of Antibacterial Azaphilone Hybrid Metabolites from Marine-Derived Aspergillus terreus PPS1

8 May 2025

Abstract excerpt

Three novel azaphilone hybrids ( 1 – 3 ) with two types of structural units, along with four known compounds ( 4 – 7 ), were obtained from the marine sediment-derived fungus Aspergillus terreus PPS1. Asperbenzophilone A ( 1 ) features an unprecedented 6/6/6/6 ring system containing a hemiketal group. Butyropyranones I and II ( 2 and 3 ) are equipped with an azaphilone fragment preasperpyranone and a...

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PMID: 40340408
DOI: 10.1021/acs.jnatprod.5c00187

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