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Deciphering the role of FUS::DDIT3 expression and tumor microenvironment in myxoid liposarcoma development

26 Apr 2024

Abstract excerpt

BACKGROUND: Myxoid liposarcoma (MLS) displays a distinctive tumor microenvironment and is characterized by the FUS::DDIT3 fusion oncogene, however, the precise functional contributions of these two elements remain enigmatic in tumor development. METHODS: To study the cell-free microenvironment in MLS, we developed an experimental model system based on decellularized patient-derived xenograft tumors. We...

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PMID: 38671504
DOI: 10.1186/s12967-024-05211-w

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