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Article

Pathological Conversion of Mouse Perivascular Adipose Tissue by Notch Activation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2020

Boucher Joshua M, Ryzhova Larisa, Harrington Anne, Davis-Knowlton Jessica, Turner Jacqueline E, Cooper Emily, Maridas David, Ryzhov Sergey, Rosen Clifford J, Vary Calvin P H, Liaw Lucy

Abstract excerpt

OBJECTIVE: Perivascular adipose tissue (PVAT) surrounding arteries supports healthy vascular function. During obesity, PVAT loses its vasoprotective effect. We study pathological conversion of PVAT, which involves molecular changes in protein profiles and functional changes in adipocytes. Approach and Results: C57BL6/J mice were fed a 60% high-fat diet for 12 weeks or a cardioprotective 30% calorie-restricted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32640901
DOI: 10.1161/ATVBAHA.120.314731
PMCID: PMC7483939

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