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Article

p53 immunohistochemistry as an ancillary tool for rapid assessment of residual disease in TP53-mutated acute myeloid leukemia and myelodysplastic syndromes.

American journal of clinical pathology - 3 Sept 2024

Brar Nivaz, Lawrence Lauren, Fung Eula, Zehnder James L, Greenberg Peter L, Mannis Gabriel N, Zhang Tian Y, Gratzinger Dita, Oak Jean, Silva Oscar, Kurzer Jason, Tan Brent, Menke Joshua R, Fernandez-Pol Sebastian

Abstract excerpt

OBJECTIVES: Measurable residual disease flow cytometry (MRD-FC) and molecular studies are the most sensitive methods for detecting residual malignant populations after therapy for TP53-mutated acute myeloid leukemia and myelodysplastic neoplasms (TP53+ AML/MDS). However, their sensitivity is limited in suboptimal aspirates or when the immunophenotype of the neoplastic blasts overlaps with erythroids or normal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38643353
DOI: 10.1093/ajcp/aqae034

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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