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Toll-like receptor activation regulates the paracrine effect of adipose-derived mesenchymal stem cells on reversing osteoarthritic phenotype of chondrocytes.

Molecular biology reports - 20 Apr 2024

Wan Zu, Wang Xin, Fu Zhenlan, Ma Yanming, Dai Gang, Gong Xiaoyuan, Chen Guangxing, Yang Liu

Abstract excerpt

BACKGROUND: The therapeutic efficacy of intra-articular mesenchymal stem cells (MSCs) injection for patients with osteoarthritis (OA) currently exhibits inconsistency, and the underlying mechanism remains elusive. It has been postulated that the immunomodulatory properties and paracrine activity of MSCs might be influenced by the inflammatory micro-environment within osteoarthritic joints, potentially...

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PMID: 38642183
DOI: 10.1007/s11033-024-09499-1

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