Article
TIM-3+ CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies.
Science immunology - 19 Apr 2024
Minnie Simone A, Waltner Olivia G, Zhang Ping, Takahashi Shuichiro, Nemychenkov Nicole S, Ensbey Kathleen S, Schmidt Christine R, Legg Samuel R W, Comstock Melissa, Boiko Julie R, Nelson Ethan, Bhise Shruti S, Wilkens Alec B, Koyama Motoko, Dhodapkar Madhav V, Chesi Marta, Riddell Stanley R, Green Damian J, Spencer Andrew, Furlan Scott N, Hill Geoffrey R
Abstract excerpt
Chronic antigen stimulation is thought to generate dysfunctional CD8 T cells. Here, we identify a CD8 T cell subset in the bone marrow tumor microenvironment that, despite an apparent terminally exhausted phenotype (TPHEX), expressed granzymes, perforin, and IFN-γ. Concurrent gene expression and DNA accessibility revealed that genes encoding these functional proteins correlated with BATF expression and motif...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.