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Article

Germline and Somatic Fumarate Hydratase Testing in Atypical Uterine Leiomyomata.

Cancer prevention research (Philadelphia, Pa.) - 2 May 2024

Kipnis Lindsay M, Breen Katelyn M, Koeller Diane R, Levine Alison Schwartz, Yang Zelei, Jun Hyeji, Tayob Nabihah, Stokes Samantha M, Hayes Connor P, Ghazani Arezou A, Hill Sarah J, Rana Huma Q

Abstract excerpt

Women with germline pathogenic variants (PV) in the fumarate hydratase (FH) gene develop cutaneous and uterine leiomyomata and have an increased risk of developing aggressive renal cell carcinomas. Many of these women are unaware of their cancer predisposition until an atypical uterine leiomyoma is diagnosed during a myomectomy or hysterectomy, making a streamlined genetic counseling process after a...

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Source

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Identifiers

PMID: 38638033
DOI: 10.1158/1940-6207.CAPR-23-0535
PMCID: PMC11439430

Genes

FH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Germline and Somatic Fumarate Hydratase Testing in Atypical Uterine Leiomyomata.PMID 38638033Read ↗

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