Uptake of Risk-Reducing Measures, Cascade Testing, and Related Challenges Among Carriers of Breast Cancer-Associated Germline Pathogenic Variants in Mexico.

doi:10.1200/GO.23.00417

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Uptake of Risk-Reducing Measures, Cascade Testing, and Related Challenges Among Carriers of Breast Cancer-Associated Germline Pathogenic Variants in Mexico.

JCO global oncology - 1 Apr 2024

Mesa-Chavez Fernanda, Chavarri-Guerra Yanin, Aguilar-Y-Mendez Dione, Becerril-Gaitan Andrea, Vaca-Cartagena Bryan F, Carrillo-Bedoya Araceli, Santiesteban-González Salvador, Aranda-Gutierrez Alejandro, Rodríguez-Faure Andrés, Obregon-Leal Daniela, Quintero-Beuló Gregorio, Rodriguez-Olivares Jose L, Miaja Melina, Weitzel Jeffrey N, Villarreal-Garza Cynthia

Abstract excerpt

PURPOSE: Genetic cancer risk assessment (GCRA) provides pathogenic variant (PV) carriers with the invaluable opportunity to undertake timely cancer risk-reducing (RR) measures and initiate cascade testing (CT). This study describes the uptake of these strategies and the related barriers among breast cancer-associated germline PV carriers in Mexico. METHODS: Carriers who were at least 6 months after disclosure of...

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Identifiers

PMID: 38635940
DOI: 10.1200/GO.23.00417
PMCID: PMC11191870

Genes

ATM
BRCA1
CHEK2
NF1
PALB2
PTEN
RAD51C
TP53

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