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Obstacles in genetic testing for germline BRCA1/2 pathogenic mutations in patients with primary breast and ovarian cancer in Switzerland.

Archives of gynecology and obstetrics - 1 Oct 2025

Braun Christian, Krautova Lucie, Schwedler Kathrin, Christmann Corina, Brambs Christine

Abstract excerpt

PURPOSE: Approximately 5-10% of breast and up to 25% of ovarian cancer cases are hereditary, predominantly associated with germline BRCA1/2 pathogenic variants. Identifying these mutations is essential for personalized treatment, prevention strategies, and cascade testing in families. However, integrating genetic testing into routine care faces substantial barriers globally and within Switzerland. METHODS: This...

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Identifiers

PMID: 40782146
DOI: 10.1007/s00404-025-08138-9
PMCID: PMC12414081

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BRCA1

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