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Article

Genetic evidence for involvement of β2-adrenergic receptor in brown adipose tissue thermogenesis in humans.

International journal of obesity (2005) - 1 Aug 2024

Ishida Yuka, Matsushita Mami, Yoneshiro Takeshi, Saito Masayuki, Fuse Sayuri, Hamaoka Takafumi, Kuroiwa Miyuki, Tanaka Riki, Kurosawa Yuko, Nishimura Takayuki, Motoi Midori, Maeda Takafumi, Nakayama Kazuhiro

Abstract excerpt

BACKGROUND: Sympathetic activation of brown adipose tissue (BAT) thermogenesis can ameliorate obesity and related metabolic abnormalities. However, crucial subtypes of the β-adrenergic receptor (AR), as well as effects of its genetic variants on functions of BAT, remains unclear in humans. We conducted association analyses of genes encoding β-ARs and BAT activity in human adults. METHODS: Single nucleotide...

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Share to Adipose Tissue, Brown
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Positron Emission Tomography Computed Tomography

Share to Receptors, Adrenergic, beta-2

Share to Receptors, Adrenergic, beta-3

Share to Thermogenesis

Source

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Identifiers

PMID: 38632325
DOI: 10.1038/s41366-024-01522-6
PMCID: PMC11281906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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