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Article

Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model.

Cell reports - 23 Apr 2024

Nakayama Takahiro, Singh Akash K, Fukutomi Toshiyuki, Uchida Noriyuki, Terao Yasuo, Hamada Hiroki, Muraoka Takahiro, Muthusamy Eswaramoorthy, Kundu Tapas K, Akagawa Kimio

Abstract excerpt

Syntaxin-1A (stx1a) repression causes a neurodevelopmental disorder phenotype, low latent inhibition (LI) behavior, by disrupting 5-hydroxytryptaminergic (5-HTergic) systems. Herein, we discovered that lysine acetyltransferase (KAT) 3B increases stx1a neuronal transcription and TTK21, a KAT3 activator, induces stx1a transcription and 5-HT release in vitro. Furthermore, glucose-derived CSP-TTK21 could restore...

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Identifiers

PMID: 38613786
DOI: 10.1016/j.celrep.2024.114101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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