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The MDM2–p53 Axis Represents a Therapeutic Vulnerability Unique to Glioma Stem Cells

2 Apr 2024

Abstract excerpt

The prevention of tumor recurrence by the successful targeting of glioma stem cells endowed with a tumor-initiating capacity is deemed the key to the long-term survival of glioblastoma patients. Glioma stem cells are characterized by their marked therapeutic resistance; however, recent evidence suggests that they have unique vulnerabilities that may be therapeutically targeted. We investigated MDM2 expression...

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PMID: 38612758
DOI: 10.3390/ijms25073948

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