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Article

mTOR Inhibition Prolongs Survival and Has Beneficial Effects on Heart Function After Onset of Lamin A/C Gene Mutation Cardiomyopathy in Mice.

Circulation. Heart failure - 1 Apr 2024

Wu Wei, Jin Qi, Östlund Cecilia, Tanji Kurenai, Shin Ji-Yeon, Han Jiying, Leu Cheng-Shiun, Kushner Jared, Worman Howard J

Abstract excerpt

BACKGROUND: Mutations in LMNA encoding nuclear envelope proteins lamin A/C cause dilated cardiomyopathy. Activation of the AKT/mTOR (RAC-α serine/threonine-protein kinase/mammalian target of rapamycin) pathway is implicated as a potential pathophysiologic mechanism. The aim of this study was to assess whether pharmacological inhibition of mTOR signaling has beneficial effects on heart function and prolongs...

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Identifiers

PMID: 38567527
DOI: 10.1161/CIRCHEARTFAILURE.123.011110
PMCID: PMC11008450

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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