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Article

Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation.

Bioorganic & medicinal chemistry - 1 Feb 2017

Wu Wei, Chordia Mahendra D, Hart Barry P, Kumarasinghe E Sathyajith, Ji Min K, Bhargava Ajay, Lawlor Michael W, Shin Ji-Yeon, Sera Fusako, Homma Shunichi, Muchir Antoine, Khire Uday R, Worman Howard J

Abstract excerpt

Signaling mediated by extracellular signal-regulated kinases 1 and 2 (ERK1/2) is involved in numerous cellular processes. Mitogen-activated protein kinase kinases (MEK1/2) catalyze the phosphorylation of ERK1/2, converting it into an active kinase that regulates the expression of numerous genes and cellular processes. Inhibitors of MEK1/2 have demonstrated preclinical and clinical efficacy in certain cancers and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28011205
DOI: 10.1016/j.bmc.2016.12.014
PMCID: PMC5291759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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