Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exome sequencing and genome-wide association analyses unveils the genetic predisposition in hydroxychloroquine retinopathy.

Eye (London, England) - 1 Jul 2024

Chiu Hsun-I, Cheng Hui-Chen, Wu Chih-Chiau, Chen Shih-Jen, Hwang De-Kuang, Huang Yi-Ming, Chou Yu-Bai, Lin Po-Kang, Lin Tai-Chi, Chen Ko-Hua, Lin Pei-Yu, Chang Yu-Fan, Wang An-Guor

Abstract excerpt

OBJECTIVES: To unveil the candidate susceptibility genes in chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy using whole exome sequencing (WES) and genome-wide association study (GWAS). METHODS: Patients with a diagnosis of CQ/HCQ retinopathy based on the comprehensive demographic and ocular examination were included. The peripheral blood was extracted for WES and GWAS analyses. The Chinese Han Southern...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Antirheumatic Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Exome Sequencing

Share to Genome-Wide Association Study

Share to Hydroxychloroquine

Share to Polymorphism, Single Nucleotide

Share to Retinal Diseases

Share to Visual Acuity

Source

Open in PubMed Open full text

Identifiers

PMID: 38548946
DOI: 10.1038/s41433-024-03044-x
PMCID: PMC11226719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exome sequencing and genome-wide association analyses unveils the genetic predisposition in hydroxychloroquine retinopathy.PMID 38548946Read ↗

Exome sequencing and genome-wide association analyses unveils the genetic predisposition in hydroxychloroquine retinopathySemantic proximity Read ↗

Genetic susceptibility to hydroxychloroquine retinal toxicity.Semantic proximity Read ↗

[Variability of chloroquine and hydroxychloroquine retinopathy among various ethnicities].Semantic proximity Read ↗

Hydroxychloroquine retinopathy in two patients with Sjögren’s syndrome: case report and literature reviewSemantic proximity Read ↗

Molecular effects and retinopathy induced by hydroxychloroquine during SARS-CoV-2 therapy: Role of CYP450 isoforms and epigenetic modulationsSemantic proximity Read ↗

Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy).Semantic proximity Read ↗

Replication analysis for severe diabetic retinopathy.Semantic proximity Read ↗

A novel KCNV2 mutation in a patient taking hydroxychloroquine associated with cone dystrophy with supernormal rod response.Semantic proximity Read ↗

Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes.Semantic proximity Read ↗

Mitochondrial haplogroups are associated with severity of diabetic retinopathy.Semantic proximity Read ↗

GLO1 gene polymorphisms and their association with retinitis pigmentosa: a case-control study in a Sicilian population.Semantic proximity Read ↗

Association of polymorphisms in the erythropoietin gene with diabetic retinopathy: a case-control study and systematic review with meta-analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.