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Article

Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy).

BMC ophthalmology - 6 Mar 2015

Grassmann Felix, Bergholz Richard, Mändl Julia, Jägle Herbert, Ruether Klaus, Weber Bernhard H F

Abstract excerpt

BACKGROUND: Chloroquine (CQ) and hydroxychloroquine (HCQ) are used to treat auto-immune related diseases such as rheumatoid arthritis (RA) or systemic lupus erythematosus. Both drugs however can cause retinal toxicity eventually leading to irreversible maculopathy and retinopathy. Established risk factors are duration and dosage of treatment while the involvement of genetic factors contributing to toxic...

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Share to Antirheumatic Agents
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25884411
DOI: 10.1186/s12886-015-0008-0
PMCID: PMC4352241

Genes

ABCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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