Article
APOE-ε4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging.
Neurobiology of aging - 1 Jun 2024
Mick Paul, Kabir Rasel, Karunatilake Malshi, Kathleen Pichora-Fuller M, Young Terry-Lyn, Sosero Yuri, Gan-Or Ziv, Wittich Walter, Phillips Natalie A
Abstract excerpt
INTRODUCTION: Hearing loss and diminished visual acuity are associated with poorer cognition, but the underlying mechanisms are not understood. The apolipoprotein (APOE) ε4 allelic variant may drive the associations. We tested whether APOE-ε4 allele count (0, 1, or 2) was associated with declines in memory, executive function, pure-tone hearing threshold averages, and pinhole-corrected visual acuity among...
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