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Article

Gene dose of apolipoprotein E and age-related hearing loss.

Neurobiology of aging - 1 Sept 2012

Kurniawan Clara, Westendorp Rudi G J, de Craen Anton J M, Gussekloo Jacobijn, de Laat Jan, van Exel Eric

Abstract excerpt

Next to outer hair cell dysfunction, age-related hearing loss may be explained by apolipoprotein E (APOE) genotype. In the Leiden 85-plus Study, a population-based study, the participants were 85 years old. We measured hearing loss by pure-tone audiometry in 435 participants in relation to APOE. Results demonstrated that those with the APOE-ε4/ε4 genotype had the highest levels of hearing loss (n = 6; 56.1 dB),...

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Source

Identifiers

PMID: 22542837
DOI: 10.1016/j.neurobiolaging.2012.04.001

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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