Article
Evaluation of Plasma Biomarkers for Causal Association With Peripheral Artery Disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2024
Sharma Pranav, Klarin Derek, Voight Benjamin F, Tsao Philip S, Levin Michael G, Damrauer Scott M
Abstract excerpt
BACKGROUND: Hundreds of biomarkers for peripheral artery disease (PAD) have been reported in the literature; however, the observational nature of these studies limits causal inference due to the potential of reverse causality and residual confounding. We sought to evaluate the potential causal impact of putative PAD biomarkers identified in human observational studies through genetic causal inference methods....
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