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Article

Red blood cells function as reservoirs of tumor DNA.

American journal of physiology. Lung cellular and molecular physiology - 1 May 2024

Thompson Jeffrey C, Li Sue, Jose Joshua S, Predina Jarrod, Gupta Aasha, Eruslanov Evgeniy, Singhal Sunil, Albelda Steven M, Mangalmurti Nilam S

Abstract excerpt

Novel screening techniques for early detection of lung cancer are urgently needed. Profiling circulating tumor cell-free DNA (ctDNA) has emerged as a promising tool for biopsy-free tumor genotyping. However, both the scarcity and short half-life of ctDNA substantially limit the sensitivity and clinical utility of ctDNA detection methodologies. Our discovery that red blood cells (RBCs) sequester mitochondrial DNA...

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Topics

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Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Circulating Tumor DNA

Share to DNA, Mitochondrial

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Source

Open in PubMed Open full text

Identifiers

PMID: 38529551
DOI: 10.1152/ajplung.00049.2024
PMCID: PMC11380936

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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