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Article

Prediction uncertainty estimates elucidate the limitation of current NSCLC subtype classification in representing mutational heterogeneity.

Scientific reports - 21 Mar 2024

Puiu Andrei, Gómez Tapia Carlos, Weiss Maximilian E R, Singh Vivek, Kamen Ali, Siebert Matthias

Abstract excerpt

The heterogeneous pathogenesis and treatment response of non-small cell lung cancer (NSCLC) has led clinical treatment decisions to be guided by NSCLC subtypes, with lung adenocarcinoma and lung squamous cell carcinoma being the most common subtypes. While histology-based subtyping remains challenging, NSCLC subtypes were found to be distinct at the transcriptomic level. However, unlike genomic alterations, gene...

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Identifiers

PMID: 38514696
DOI: 10.1038/s41598-024-57057-3
PMCID: PMC10958018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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