Article
Ancestry-Associated Performance Variability of Open-Source AI Models for EGFR Prediction in Lung Cancer.
JAMA oncology - 1 Apr 2026
Rakaee Mehrdad, Nassar Amin H, Tafavvoghi Masoud, Jabar Falah, Bou Farhat Elias, Adib Elio, Andersen Sigve, Busund Lill-Tove Rasmussen, Pøhl Mette, Helland Åslaug, Gusev Alexander, Ricciuti Biagio, Sholl Lynette M, Donnem Tom, Kwiatkowski David J
Abstract excerpt
Importance: Artificial intelligence (AI) models are emerging as rapid, low-cost tools for predicting targetable genomic alterations directly from routine pathology slides. Although these approaches could accelerate treatment decisions in lung cancer, little is known about whether their performance is consistent across diverse patient populations and tissue contexts. Objective: To evaluate the performance and...
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