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Article

Dissecting AI-based mutation prediction in lung adenocarcinoma: A comprehensive real-world study.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2024

Dernbach Gabriel, Kazdal Daniel, Ruff Lukas, Alber Maximilian, Romanovsky Eva, Schallenberg Simon, Christopoulos Petros, Weis Cleo-Aron, Muley Thomas, Schneider Marc A, Schirmacher Peter, Thomas Michael, Müller Klaus-Robert, Budczies Jan, Stenzinger Albrecht, Klauschen Frederick

Abstract excerpt

INTRODUCTION: Molecular profiling of lung cancer is essential to identify genetic alterations that predict response to targeted therapy. While deep learning shows promise for predicting oncogenic mutations from whole tissue images, existing studies often face challenges such as limited sample sizes, a focus on earlier stage patients, and insufficient analysis of robustness and generalizability. METHODS: This...

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PMID: 39276594
DOI: 10.1016/j.ejca.2024.114292

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