Article
Stratification of Sepsis Patients on Admission into the Intensive Care Unit According to Differential Plasma Metabolic Phenotypes.
Journal of proteome research - 5 Apr 2024
Lodge Samantha, Litton Edward, Gray Nicola, Ryan Monique, Millet Oscar, Fear Mark, Raby Edward, Currie Andrew, Wood Fiona, Holmes Elaine, Wist Julien, Nicholson Jeremy K
Abstract excerpt
Delayed diagnosis of patients with sepsis or septic shock is associated with increased mortality and morbidity. UPLC-MS and NMR spectroscopy were used to measure panels of lipoproteins, lipids, biogenic amines, amino acids, and tryptophan pathway metabolites in blood plasma samples collected from 152 patients within 48 h of admission into the Intensive Care Unit (ICU) where 62 patients had no sepsis, 71 patients...
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