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Article

LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4.

Biology direct - 19 Mar 2024

Li Zhenchong, Ma Zuyi, Wang Shujie, Yan Qian, Zhuang Hongkai, Zhou Zixuan, Liu Chunsheng, Chen Yubin, Han Mingqian, Wu Zelong, Huang Shanzhou, Zhou Qi, Hou Baohua, Zhang Chuanzhao

Abstract excerpt

BACKGROUND: Pancreatic cancer stem cells are crucial for tumorigenesis and cancer metastasis. Presently, long non-coding RNAs were found to be associated with Pancreatic Ductal Adenocarcinoma stemness characteristics but the underlying mechanism is largely known. Here, we aim to explore the function of LINC00909 in regulating pancreatic cancer stemness and cancer metastasis. METHODS: The expression level and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38504385
DOI: 10.1186/s13062-024-00463-4
PMCID: PMC10949730

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