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Article

MYB alternative promoter activity is increased in adenoid cystic carcinoma metastases and is associated with a specific gene expression signature

16 Mar 2024

Abstract excerpt

OBJECTIVE: Adenoid cystic carcinoma (ACC) is a head and neck cancer with a poor long-term prognosis that shows frequent local recurrences and distant metastases. The tumors are characterized by MYB oncogene activation and are notoriously unresponsive to systemic therapies. The biological underpinnings behind therapy resistance of disseminated ACC are largely unknown. Here, we have studied the molecular and...

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Share to Head and Neck Surgical Oncology
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38493544
DOI: 10.1016/j.oraloncology.2024.106763

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