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Cholangiocarcinoma Malignant Traits Are Promoted by Schwann Cells through TGFβ Signaling in a Model of Perineural Invasion.

Cells - 20 Feb 2024

de Franchis Valerio, Petrungaro Simonetta, Pizzichini Elisa, Camerini Serena, Casella Marialuisa, Somma Francesca, Mandolini Enrico, Carpino Guido, Overi Diletta, Cardinale Vincenzo, Facchiano Antonio, Filippini Antonio, Gaudio Eugenio, Fabrizi Cinzia, Giampietri Claudia

Abstract excerpt

The term cholangiocarcinoma (CCA) defines a class of epithelial malignancies originating from bile ducts. Although it has been demonstrated that CCA patients with perineural invasion (PNI) have a worse prognosis, the biological features of this phenomenon are yet unclear. Our data show that in human intrahepatic CCA specimens with documented PNI, nerve-infiltrating CCA cells display positivity of the epithelial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38474330
DOI: 10.3390/cells13050366
PMCID: PMC10930666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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