Article
IDH-mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation.
Blood - 2 May 2024
Hong Lih En, Wechalekar Mihir D, Kutyna Monika, Small Annabelle, Lim Kelly, Thompson-Peach Chloe, Li Joule J, Chhetri Rakchha, Scott Hamish S, Brown Anna, Hahn Christopher N, Yeung David T, Sajid Salvia, Robinson Nirmal, Thomas Ranjeny, Branford Susan, D'Andrea Richard J, Samaraweera Saumya E, Patnaik Mrinal, Proudman Susanna, Thomas Daniel, Kok Chung Hoow, Shah Mithun V, Hiwase Devendra K
Abstract excerpt
ABSTRACT: High prevalence of IDH mutations in seronegative rheumatoid arthritis (RA) with myeloid neoplasm, elevated 2-hydroxyglutarate, dysregulated innate immunity, and proinflammatory microenvironment suggests causative association between IDH mutations and seronegative RA. Our findings merit investigation of IDH inhibitors as therapeutics for seronegative IDH-mutated RA.
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