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Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8 + T cell responses

6 Mar 2024

Abstract excerpt

Coxsackievirus B (CVB) infection of pancreatic β cells is associated with β cell autoimmunity and type 1 diabetes. We investigated how CVB affects human β cells and anti-CVB T cell responses. β cells were efficiently infected by CVB in vitro, down-regulated human leukocyte antigen (HLA) class I, and presented few, selected HLA-bound viral peptides. Circulating CD8 + T cells from CVB–seropositive individuals...

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PMID: 38446892
DOI: 10.1126/sciadv.adl1122

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