ctDNA improves prognostic prediction for patients with relapsed/refractory MM receiving ixazomib, lenalidomide, and dexamethasone.

doi:10.1182/blood.2023022540

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Article

ctDNA improves prognostic prediction for patients with relapsed/refractory MM receiving ixazomib, lenalidomide, and dexamethasone.

Blood - 6 Jun 2024

Kogure Yasunori, Handa Hiroshi, Ito Yuta, Ri Masaki, Horigome Yuichi, Iino Masaki, Harazaki Yoriko, Kobayashi Takahiro, Abe Masahiro, Ishida Tadao, Ito Shigeki, Iwasaki Hiromi, Kuroda Junya, Shibayama Hirohiko, Sunami Kazutaka, Takamatsu Hiroyuki, Tamura Hideto, Hayashi Toshiaki, Akagi Kiwamu, Shinozaki Tomohiro, Yoshida Takahiro, Mori Ikuo, Iida Shinsuke, Maeda Takahiro, Kataoka Keisuke

Abstract excerpt

ABSTRACT: It remains elusive how driver mutations, including those detected in circulating tumor DNA (ctDNA), affect prognosis in relapsed/refractory multiple myeloma (RRMM). Here, we performed targeted-capture sequencing using bone marrow plasma cells (BMPCs) and ctDNA of 261 RRMM cases uniformly treated with ixazomib, lenalidomide, and dexamethasone in a multicenter, prospective, observational study. We...

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PMID: 38427753
DOI: 10.1182/blood.2023022540

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