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Low-temperature culture enhances production of flavivirus virus-like particles in mammalian cells

28 Feb 2024

Abstract excerpt

Flavivirus virus-like particles (VLPs) exhibit a striking structural resemblance to viral particles, making them highly adaptable for various applications, including vaccines and diagnostics. Consequently, increasing VLPs production is important and can be achieved by optimizing expression plasmids and cell culture conditions. While attempting to express genotype III (GIII) Japanese encephalitis virus (JEV) VLPs...

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PMID: 38416210
DOI: 10.1007/s00253-024-13064-y

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