Article
Structural models of genome-wide covariance identify multiple common dimensions in autism.
Nature communications - 27 Feb 2024
de Hoyos Lucía, Barendse Maria T, Schlag Fenja, van Donkelaar Marjolein M J, Verhoef Ellen, Shapland Chin Yang, Klassmann Alexander, Buitelaar Jan, Verhulst Brad, Fisher Simon E, Rai Dheeraj, St Pourcain Beate
Abstract excerpt
Common genetic variation has been associated with multiple phenotypic features in Autism Spectrum Disorder (ASD). However, our knowledge of shared genetic factor structures contributing to this highly heterogeneous phenotypic spectrum is limited. Here, we developed and implemented a structural equation modelling framework to directly model genomic covariance across core and non-core ASD phenotypes, studying...
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