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Article

Clinical autism subscales have common genetic liabilities that are heritable, pleiotropic, and generalizable to the general population.

Translational psychiatry - 13 Jun 2022

Thomas Taylor R, Koomar Tanner, Casten Lucas G, Tener Ashton J, Bahl Ethan, Michaelson Jacob J

Abstract excerpt

The complexity of autism's phenotypic spectra is well-known, yet most genetic research uses case-control status as the target trait. It is undetermined if autistic symptom domain severity underlying this heterogeneity is heritable and pleiotropic with other psychiatric and behavior traits in the same manner as autism case-control status. In N = 6064 autistic children in the SPARK cohort, we investigated the...

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PMID: 35697691
DOI: 10.1038/s41398-022-01982-2
PMCID: PMC9192633

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