Comprehensive morphologic characterization of bone marrow biopsy findings in a large cohort of patients with VEXAS syndrome: A single-institution longitudinal study of 111 bone marrow samples from 52 patients.

doi:10.1093/ajcp/aqad186

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Comprehensive morphologic characterization of bone marrow biopsy findings in a large cohort of patients with VEXAS syndrome: A single-institution longitudinal study of 111 bone marrow samples from 52 patients.

American journal of clinical pathology - 3 Jun 2024

Olteanu Horatiu, Patnaik Mrinal, Koster Matthew J, Herrick Jennifer L, Chen Dong, He Rong, Viswanatha David, Warrington Kenneth J, Go Ronald S, Mangaonkar Abhishek A, Kourelis Taxiarchis, Hines Alexander, Gibson Sarah E, Peterson Jess F, Reichard Kaaren K

Abstract excerpt

OBJECTIVES: VEXAS syndrome is an adult-onset autoinflammatory disease caused by a somatic pathogenic mutation in the UBA1 (ubiquitin-like modifier activating enzyme 1) gene. Patients present with rheumatologic manifestations and cytopenias and may have an increased predisposition to myelodysplastic syndrome (MDS) and plasma cell neoplasms. Prior studies have reported on the peripheral blood and bone marrow...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biopsy

Share to Bone Marrow

Share to Cohort Studies

Share to Longitudinal Studies

Share to Myelodysplastic Syndromes

Share to Thrombocytopenia

Share to Ubiquitin-Activating Enzymes

Source

Open in PubMed

Identifiers

PMID: 38413044
DOI: 10.1093/ajcp/aqad186

Genes

UBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive morphologic characterization of bone marrow biopsy findings in a large cohort of patients with VEXAS syndrome: A single-institution longitudinal study of 111 bone marrow samples from 52 patients.PMID 38413044Read ↗

Characteristic bone marrow findings in patients with UBA1 somatic mutations and VEXAS syndrome.Semantic proximity Read ↗

A clinical, histopathological, and molecular study of two cases of VEXAS syndrome without a definitive myeloid neoplasm.Semantic proximity Read ↗

Benign and malignant hematologic manifestations in patients with VEXAS syndrome due to somatic mutations in UBA1.Semantic proximity Read ↗

Case report of a patient with VEXAS syndrome.Semantic proximity Read ↗

Morphologic Deciphering of Hematopoietic Cell Vacuolization: Lessons From VEXAS Syndrome and Other Etiologies.Semantic proximity Read ↗

How I diagnose and manage VEXAS syndrome.Semantic proximity Read ↗

American College of Rheumatology Guidance Statement for Diagnosis and Management of VEXAS Developed by the International VEXAS Working Group Expert Panel.Semantic proximity Read ↗

VEXAS syndrome: Clinical, hematologic features and a practical approach to diagnosis and management.Semantic proximity Read ↗

VEXAS syndrome in adults: A narrative review of genomic pathogenesis, multisystem phenotypes, diagnostic algorithms, and emerging therapeutic strategies.Semantic proximity Read ↗

VEXAS syndrome: a new paradigm for adult-onset monogenic autoinflammatory diseases.Semantic proximity Read ↗

VEXAS syndrome, a new kid on the block of auto-inflammatory diseases: A hematologist's point of view.Semantic proximity Read ↗

Clinical and genetic features of Japanese cases of MDS associated with VEXAS syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.