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Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15

24 Feb 2024

Abstract excerpt

Abstract Fusobacterium nucleatum ( F. nucleatum ) promotes intestinal tumor growth and its relative abundance varies greatly among patients with CRC, suggesting the presence of unknown, individual-specific effectors in F. nucleatum -dependent carcinogenesis. Here, we identify that F. nucleatum is enriched preferentially in KRAS p.G12D mutant CRC tumor tissues and contributes to colorectal tumorigenesis in...

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PMID: 38402201
DOI: 10.1038/s41467-024-45572-w

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